Ming-Hsien Chien Selected Research

Neoplasm Metastasis (Metastasis)

1/2024	Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma.
10/2023	Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer.
6/2023	Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer.
1/2023	Proteoglycan SPOCK1 as a Poor Prognostic Marker Promotes Malignant Progression of Clear Cell Renal Cell Carcinoma via Triggering the Snail/Slug-MMP-2 Axis-Mediated Epithelial-to-Mesenchymal Transition.
6/2022	Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer.
10/2021	Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.
1/2021	Direct interaction of β-catenin with nuclear ESM1 supports stemness of metastatic prostate cancer.
1/2021	Combined Impacts of Genetic Variants of Long Non-Coding RNA MALAT1 and the Environmental Carcinogen on the Susceptibility to and Progression of Oral Squamous Cell Carcinoma.
11/2020	Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer.
9/2020	Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.

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Ming-Hsien Chien Research Topics

Disease

91	Neoplasms (Cancer) 04/2024 - 06/2008
39	Neoplasm Metastasis (Metastasis) 01/2024 - 10/2010
17	Squamous Cell Carcinoma of Head and Neck 01/2024 - 01/2012
16	Hepatocellular Carcinoma (Hepatoma) 10/2022 - 09/2011
15	Mouth Neoplasms (Oral Cancer) 01/2022 - 10/2010
11	Prostatic Neoplasms (Prostate Cancer) 10/2023 - 04/2014
11	Carcinogenesis 01/2022 - 01/2012
11	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2020 - 12/2009
10	Pneumonia (Pneumonitis) 12/2016 - 11/2011
9	Lung Neoplasms (Lung Cancer) 06/2023 - 10/2010
7	Adenocarcinoma of Lung 10/2021 - 05/2012
7	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 04/2017
6	Leukemia 01/2018 - 12/2009
6	Inflammation (Inflammations) 01/2016 - 10/2010
5	Renal Cell Carcinoma (Grawitz Tumor) 08/2023 - 04/2016
5	Lymphatic Metastasis 01/2021 - 04/2012
5	Carcinoma (Carcinomatosis) 02/2019 - 01/2012
4	Glioblastoma (Glioblastoma Multiforme) 10/2020 - 01/2015
3	Infections 12/2018 - 12/2011
3	Osteosarcoma (Osteogenic Sarcoma) 10/2018 - 02/2015
3	Head and Neck Neoplasms (Head and Neck Cancer) 01/2018 - 02/2013
3	Hypoxia (Hypoxemia) 10/2017 - 05/2012
3	Breast Neoplasms (Breast Cancer) 02/2017 - 01/2012
3	Uterine Cervical Neoplasms (Cancer of the Cervix) 02/2014 - 01/2014
2	Confusion (Bewilderment) 01/2016 - 07/2013

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 11/2023 - 02/2011
9	FlavonoidsIBA 01/2024 - 01/2015
7	Environmental CarcinogensIBA 01/2018 - 01/2012
6	CytokinesIBA 06/2023 - 10/2010
6	Matrix Metalloproteinases (MMPs)IBA 01/2023 - 05/2012
6	MelatoninIBA 09/2020 - 04/2016
6	Matrix Metalloproteinase 9 (Gelatinase B)IBA 10/2017 - 11/2011
6	Vascular Endothelial Growth Factor CIBA 05/2014 - 06/2008
5	Proteoglycans (Proteoglycan)IBA 01/2023 - 06/2019
5	Antipsychotic Agents (Antipsychotics)IBA 06/2022 - 01/2019
5	Penfluridol (Semap)IBA 06/2022 - 01/2019
5	CurcuminIBA 01/2022 - 05/2015
5	Biomarkers (Surrogate Marker)IBA 04/2021 - 11/2011
5	Matrix Metalloproteinase 2 (Gelatinase A)IBA 10/2018 - 03/2012
5	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2018 - 05/2015
5	Carbonic Anhydrase IXIBA 10/2017 - 01/2012
4	ApigeninIBA 01/2024 - 02/2017
4	AcetyltransferasesIBA 11/2023 - 02/2011
4	Glycoproteins (Glycoprotein)IBA 10/2023 - 12/2012
4	Long Noncoding RNAIBA 10/2022 - 02/2019
4	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2022 - 01/2012
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2014
4	CaspasesIBA 03/2020 - 01/2014
4	Lipocalin-2IBA 01/2016 - 12/2012
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2016 - 04/2013
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2014 - 12/2009
3	EnzymesIBA 04/2024 - 01/2018
3	InterleukinsIBA 06/2023 - 04/2012
3	Tissue Inhibitor of Metalloproteinase-3IBA 12/2022 - 10/2019
3	Adenosine Triphosphate (ATP)IBA 06/2022 - 01/2019
3	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 01/2018
3	ErbB Receptors (EGF Receptor)IBA 10/2021 - 01/2018
3	Messenger RNA (mRNA)IBA 05/2021 - 09/2014
3	Histone MethyltransferasesIBA 05/2021 - 10/2010
3	RNA (Ribonucleic Acid)IBA 01/2021 - 10/2017
3	garcinolIBA 10/2020 - 03/2014
3	Tyrosine Kinase InhibitorsIBA 01/2020 - 01/2018
3	LigandsIBA 01/2020 - 10/2010
3	JNK Mitogen-Activated Protein KinasesIBA 10/2018 - 11/2016
3	ChemokinesIBA 10/2018 - 10/2010
3	norcantharidinIBA 04/2018 - 01/2012
3	QuercetinIBA 10/2017 - 07/2015
3	NF-kappa B (NF-kB)IBA 01/2017 - 01/2012
3	Cadherins (E-Cadherin)IBA 12/2015 - 09/2011
2	Monoamine Oxidase (MAO)IBA 04/2024 - 04/2020
2	Metalloproteases (Metalloproteinases)IBA 01/2024 - 09/2020
2	DisintegrinsIBA 01/2024 - 09/2020
2	ThrombospondinsIBA 01/2024 - 09/2020
2	ChitinasesIBA 10/2023 - 01/2014
2	Gemcitabine FDA Link 10/2023 - 01/2017
2	Interleukin-17 (Interleukin 17)IBA 06/2023 - 01/2021
2	OsteonectinIBA 01/2023 - 06/2019
2	CarcinogensIBA 01/2022 - 01/2021
2	Dopamine Receptors (Dopamine Receptor)IBA 01/2022 - 01/2018
2	Cisplatin (Platino)FDA LinkGeneric 10/2021 - 01/2014
2	CateninsIBA 01/2021 - 12/2018
2	demethoxycurcuminIBA 08/2020 - 03/2020
2	p38 Mitogen-Activated Protein KinasesIBA 08/2020 - 01/2014
2	AndrogensIBA 01/2020 - 08/2015
2	VA 061 (VA061)IBA 01/2020 - 08/2015
2	Stem Cell FactorIBA 01/2019 - 12/2018
2	Histones (Histone)IBA 01/2018 - 02/2017
2	tricetinIBA 07/2017 - 01/2015
2	Melatonin Receptors (Melatonin Receptor)IBA 01/2017 - 01/2015
2	MicroRNAs (MicroRNA)IBA 01/2017 - 01/2012
2	GlutaminaseIBA 01/2017 - 12/2016
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 12/2016 - 01/2013
2	Urea (Carbamide)FDA LinkGeneric 01/2016 - 07/2013
2	osthol (osthole)IBA 08/2015 - 05/2012
2	CoumarinsIBA 08/2015 - 05/2012
2	ResveratrolIBA 02/2015 - 01/2014
2	Caspase 8 (Caspase-8)IBA 12/2014 - 10/2013

Therapy/Procedure

16	Therapeutics 11/2023 - 03/2011
6	Drug Therapy (Chemotherapy) 10/2023 - 01/2017
2	Prostatectomy (Retropubic Prostatectomy) 07/2016 - 04/2014